Antimicrobial susceptibility test
In 1961, Ericsson and Sherris in collaboration with the World Health Organization undertook an initiative to define and standardize susceptibility testing on a global level. Experts from 16 countries stretching from the United States across to Japan contributed to this, which, in its time, was a monumental effort to obtain global consensus on the standardization of susceptibility testing with MIC and disk diffusion methods. The findings and recommendations of this project were published in the Acta Pathologica et Microbiologica Scandinavica and titled “Antibiotic sensitivity testing, report from an International Collaborative Study (ICS)”. This comprehensive reference, which has been cited over 5,000 times in the peer reviewed literature, was taken one step further by the Clinical Laboratory Standards Institute (CLSI) formerly NCCLS in the United States to develop specific clinical laboratory standards for antimicrobial susceptibility testing. In the meantime, the Food and Drug Administration (FDA) began its efforts to define the quality specifications of antibiotic disk reagents based on the efforts and findings of Ericsson et al. and to regulate their use for clinical testing.